Los Santos is a major city located in southern San Andreas in Grand Theft Auto V. GTA V marks Los Santos' second appearance in the series after Grand Theft Auto: San Andreas, which came out in 2004. The new rendition of the city is much more detailed, larger, and looks more alive than ever before. Los Santos is based on Los Angeles, California and its greater metropolitan area. Los Santos is Spanish for "The Saints", a play on "The Angels", which is the translation of Los Angeles.
Like its real-life counterpart, Los Santos is a huge and sprawling metropolis with various different cultures, ranging from the prestigious film-making industry of Vinewood to the suburban hood life of Strawberry, just to name a few. Like Liberty City in Grand Theft Auto IV, the time and date of the city is the same as the year the game was released (2013).
Los Santos serves as the County Seat of Los Santos County, the most developed and populated county in southern San Andreas.